2021.12.04 06:50 LandofLund Kya shakal hai, kya mamme hai, kya tangey hai....
|submitted by LandofLund to sexy_reallife_ladiess [link] [comments]|
2021.12.04 06:50 wellhouseeee No one cares about your sex life
You like to have sex often? thats great. You have multiple partners? that’s cool too, hope you’re staying safe though. You loooove it aswell? knock yourself out. This isn’t a jab at my fellow intercourse admirers, but literally no one cares about how much sex you have, how often or how good you are at it. If thats all you have to say about yourself, than you have alot to work on. Also, sex isnt everything either in a relationship or in life— go touch some grass and take a hike! Or just masterbate.
submitted by wellhouseeee to unpopularopinion [link] [comments]
2021.12.04 06:50 redz1900 It's been 10 years, but do you remember us? ❤ 【Go! Go! Nippon! Live With You!】
|submitted by redz1900 to animegifs [link] [comments]|
2021.12.04 06:50 AutoNewspaperAdmin [World] - Where does Iran’s nuclear deal stand after seven rounds of talks? | Al Jazeera
|submitted by AutoNewspaperAdmin to AutoNewspaper [link] [comments]|
2021.12.04 06:50 Ricosss Treatments for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies (Pub date: 3 dec 2021)
Abstract Various skeletal muscle abnormalities are known to occur in heart failure (HF), and are closely associated with exercise intolerance. Particularly, abnormal energy metabolism caused by mitochondrial dysfunction in skeletal muscle is a cause of decreased endurance exercise capacity. However, to date, no specific drug treatment has been established for the skeletal muscle abnormalities and exercise intolerance occurring in HF patients. Sodium-glucose transporter 2 (SGLT2) inhibitors promote glucose excretion by suppressing glucose reabsorption in the renal tubules, which has a hypoglycemic effect independent of insulin secretion. Recently, large clinical trials have demonstrated that treatment with SGLT2 inhibitors suppresses cardiovascular events in patients who have HF with systolic dysfunction. Mechanisms of the therapeutic effects of SGLT2 inhibitors for HF have been suggested to be diuretic, suppression of neurohumoral factor activation, renal protection, and improvement of myocardial metabolism, but has not been clarified to date. SGLT2 inhibitors are known to increase blood ketone bodies. This suggests that they may improve the abnormal skeletal muscle metabolism in HF, i.e., improve fatty acid metabolism, suppress glycolysis, and utilize ketone bodies in mitochondrial energy production. Ultimately, they may improve aerobic metabolism in skeletal muscle, and suppress anaerobic metabolism and improve aerobic exercise capacity at the level of the anaerobic threshold. The potential actions of such SGLT2 inhibitors explain their effectiveness in HF, and may be candidates for new drug treatments aimed at improving exercise intolerance. In this review, we outlined the effects of SGLT2 inhibitors on skeletal muscle metabolism, with a particular focus on ketone metabolism.
submitted by Ricosss to ketoscience [link] [comments]
2021.12.04 06:50 mycryptobook 🔥OTIUM GIVEAWAY! 5 WINNERS 🔥 Any purchase of 0.2 BNB or more will qualify to win 0.5 BNB (3 WINNERS) + TOP 2 buys will automatically win 1 BNB (2 WINNERS) 🔥 Conditions: Multiple entries allowed | Must Hold $OTIUM during contest | Min of 50 entries in total | Ends: Dec 6th 11.59PM UTC
|submitted by mycryptobook to cryptomoongroup [link] [comments]|
2021.12.04 06:50 magx01 I'm not going to lie and I am a nobody really but if you are new to this I promise you.....
I am not going to lie and say I am not a bit 'shook' at the moment. Not with respect to cro specifically but the overall market.
As humans are largely emotional creatures this is to be expected. What does the rational mind (and the historical data) say? It says that this is temporary.
And I don't mean this as hopium. There is always a recovery and especially for coins like cro which have an excellent use case. Cro is so heavily tied into the crypto.com ecosystem that to me it's as safe as any coin can be imo.
During times like this some alts' truly do never recover. Cro, as far as I can see it, cannot be one of these. The way they have intertwined cro with the overall crypto.com ecosystem gives it excellent longevity and market resistance. As long as there is still crpyto.com there will always be cro.
Now, if your money would better serve you financially or better serve your piece of mind being in your bank account at a time like this then by all means, sell and we will see you in the new year. It's not like cro is going to be $4 in two months. You have plenty of time to by buy back in.
But if you don't necessarily need the money right now and you believe what I am saying to be true, you should be all good.
And for you lucky/smart ones who aren't over-leveraged and have extra fiat available for times like this, enjoy your amazing buying opportunity. I wish I was one of you but I fell a bit too hard for the bull run excitement and am tapped out at the moment. Not at the point of having to panic sell (I made sure to stay ahead of this limit) but definitely cannot take advantage of this buying opportunity. Lesson learned on that one.
Yes I am scared. But that's to be expected. Some coins may not survive this. Is cro one of them? I really do not see how that would be the case. Truly.
Good luck everyone and god/universe bless.
submitted by magx01 to cro [link] [comments]
2021.12.04 06:50 Unaffectionatekat I just got out of a 3 yr relationship, but I’m more upset about losing my best friend
My (19F) and my bf (22M) were in a relationship for 3 years. It was amazing and he was my best friend, but at the 2 1/2 year mark things started to go downhill. I started losing feelings and a week after our 3 year anniversary something came up that made me realize I needed to take care of myself mentally. As much as I loved him, I was not treating him how he deserved to be treated, so we decided on a break. During that break though, I slept with someone else, and it hurt him, so he decided to end things for good. I’m not gonna lie. I’m not okay mentally, sleeping has been really hard, my thoughts have been all over the place. For some reason today, he was constantly on my mind so I decided to reach out (that was a mistake). I texted him around 1am, not expecting a response, it was just a simple “Been thinking about you, hope all is well, sorry for the late text”. To my surprise he answered right away. Things were okay, but I could quickly tell that he didn’t want to speak to me so I kept trying to excuse myself and end the conversation. But by me doing that he proceeded to tell me off and that nothing revolves around me, to get over myself. I was in shock, during our relationship he never once talked down to me, berated me, raised his voice at me. I mean, he never even really argued with me. Even after we broke up he was still so sweet checking up on me, but after tonight I feel like I lost him for good, even as a friend and I think that hurt more than the break up itself.
submitted by Unaffectionatekat to BreakUps [link] [comments]
2021.12.04 06:50 DangerStranger138 Fair and balanced.
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2021.12.04 06:50 zeropsicologos El poder curativo de la naturaleza
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2021.12.04 06:50 Relapse-then-Recover We need to make the enhanced vaccine certificate the only valid way to prove vaccination among Canadians
As someone who works in the hospitality industry, the sheer amount of different vaccine passports makes it almost impossible to identify fake/modified proof of vaccination.
The other day I asked somebody for proof of vaccination and ID and they proceeded to show me the old certificate without the QR code with a name in a different font. I've seen print outs of the passport laminated where the QR code doesn't work. I also had a gentleman come in with proof of vaccination from prison which had no QR code.
The problem with this is that it's far too easy to bypass the current system, I'm only required to attempt to scan the QR code and if it doesn't work I can base it off of the name and photo ID. The system is a joke, the only logical option is to make the enhanced certificate the official and only way to prove vaccination status (for Canadians). The current system is far too easy to manipulate and abuse.
submitted by Relapse-then-Recover to ottawa [link] [comments]
2021.12.04 06:50 iWantATree ---
2021.12.04 06:50 Wkalyakam My handsome boy 🥰
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2021.12.04 06:50 Dharmatolog Yeah right! Keep saying %9.5 is problematic. 12 out of 14 hotspots of mine have flat line!
|submitted by Dharmatolog to HeliumNetwork [link] [comments]|
2021.12.04 06:50 1aash a quick sketch of sucrose in a corset :) im only starting out as an artist and still have alot to improve on!
|submitted by 1aash to GenshinImpact [link] [comments]|
2021.12.04 06:50 oilfloatsinwater Fortnite Chapter 3 Gameplay Trailer has been leaked by Fortnite's Polish account
2021.12.04 06:50 TSM_Hooks85 Is MCA selctor not working properly?
When i try to edit my current world places i have 100% explorered are not being rendered in the software. is this a known issue or a problem I need to figure out?
submitted by TSM_Hooks85 to Minecraft [link] [comments]
2021.12.04 06:50 1BitcoinWebsite 1 Bitcoin Cash
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2021.12.04 06:50 AjKind999 👍❤️🙏
|submitted by AjKind999 to AxieScholarships [link] [comments]|
2021.12.04 06:50 The-Fezatron Wrong type of trees there
|submitted by The-Fezatron to lostredditors [link] [comments]|
2021.12.04 06:50 Rav3NPa1nts My new Experimental Rammus build
Hello, armordillo enthusiasts. Today i have a build for you. This build focuses on making your W deal as much damage as you can while tanking everything. The items are: Evenshroud - The passive makes it so enemies take more damage from all sources when you taunt them. Plated steelcaps - More armor, less problems. Demonic embrace - The burn applies from your passive so you get rewarded for taking damage while the enemy gets punished for dealing damage. Also the passive gives tanks free ap. Abyssal Mask - Reduces the enemy's magic resist when you taunt them so they take more damage from your passive, W and Demonic embrace.
Frozen Heart - damage reduction is great for making ad characters hate their lives.
Gargoyle stoneplate - Shield is great for surviving in teamfights on top of having a shitload of armor. It also gives you magic resist so there's that.
The runes are Aftershock with Demolish, Conditioning and Overgrowth. The secondary runes are sorcery with Celerity and Nullifying Orb.
I grant this build for your use. Go forth and make ADC mains want to kill themselves.
submitted by Rav3NPa1nts to RammusMains [link] [comments]
2021.12.04 06:50 VelvetCumbersnatch Only in Gloucester 😲😲😲😲
|submitted by VelvetCumbersnatch to CasualUK [link] [comments]|
2021.12.04 06:50 oshjone “it said somethin’ about the brainless man”
|submitted by oshjone to rickygervais [link] [comments]|
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2021.12.04 06:50 Ok-Repair2418 Trading 46 robux+tax